H2N2V1, Main, Exploration, bibRecord, 002A70

Effect of Priming Infection on Serologic Response to Whole and Subunit Influenza Virus Vaccines in Animals

Identifieur interne : 002A70 ( Main/Exploration ); précédent : 002A69; suivant : 002A71

Effect of Priming Infection on Serologic Response to Whole and Subunit Influenza Virus Vaccines in Animals

Auteurs : Colin Mclaren [États-Unis] ; Martha W. Verbonitz [États-Unis] ; Sylvester Daniel [États-Unis] ; George E. Grubbs [États-Unis] ; Francis A. Ennis [États-Unis]

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1977.

RBID : ISTEX:87EF8CA5C2C8F94617D41974E2F4F64C29B48EFF

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antiviraux (biosynthèse), Antigènes viraux, Cricetinae, Grippe humaine (immunologie), Humains, New Jersey, Souris, Vaccins antigrippaux (pharmacologie), Virus de la grippe A (immunologie).
MESH :
- biosynthèse : Anticorps antiviraux.
- immunologie : Grippe humaine, Virus de la grippe A.
- pharmacologie : Vaccins antigrippaux.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes viraux, Cricetinae, Humains, New Jersey, Souris.

English descriptors

KwdEn :
- Adolescent, Adult, Animals, Antibodies, Viral (biosynthesis), Antigens, Viral, Cricetinae, Humans, Influenza A virus (immunology), Influenza Vaccines (pharmacology), Influenza, Human (immunology), Mice, Middle Aged, New Jersey.
MESH :
- chemical , biosynthesis : Antibodies, Viral.
- chemical , pharmacology : Influenza Vaccines.
- geographic : New Jersey.
- immunology : Influenza A virus, Influenza, Human.
- Adolescent, Adult, Animals, Antigens, Viral, Cricetinae, Humans, Mice, Middle Aged.

Abstract

Results from studies in humans demonstrated that the serologic responses to Aj New Jersey (NJ)/76 virus vaccines varied according to the age of the vaccinee and appeared to be related to previous exposure of vaccinees to the different strains of influenza A virus. Experiments in animals were therefore performed to investigate the role of previous infection on responses to A/NJ/76 virus vaccines. Mice were infected with influenza A viruses representative of the major strains (Hsw1N1, H0N1, H2N2, H3N2) and later inoculated with various doses of whole or subunit A/NJ/76 virus vaccines. Results from experiments in mice demonstrated a low antigenicity of the subunit vaccine in unprimed animals compared with that of whole-virus vaccine; however, the antigenicity of both vaccines was enhanced in mice primed by previous infection with HO and H1 viruses. In hamsters previously infected with an H3N2 virus, however, the response to only the whole-virus vaccine was enhanced by the priming infection. The responses of the mice were qualitatively more similar to those of humans than were the responses of hamsters.

Url:

https://api.istex.fr/ark:/67375/HXZ-MK4KGJV7-W/fulltext.pdf

DOI: 10.1093/infdis/136.Supplement_3.S706

Affiliations:

Le document en format XML

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<term>Antigens, Viral</term>
<term>Cricetinae</term>
<term>Humans</term>
<term>Influenza A virus (immunology)</term>
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<term>Antigènes viraux</term>
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<term>Grippe humaine (immunologie)</term>
<term>Humains</term>
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<term>Souris</term>
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<front><div type="abstract">Results from studies in humans demonstrated that the serologic responses to Aj New Jersey (NJ)/76 virus vaccines varied according to the age of the vaccinee and appeared to be related to previous exposure of vaccinees to the different strains of influenza A virus. Experiments in animals were therefore performed to investigate the role of previous infection on responses to A/NJ/76 virus vaccines. Mice were infected with influenza A viruses representative of the major strains (Hsw1N1, H0N1, H2N2, H3N2) and later inoculated with various doses of whole or subunit A/NJ/76 virus vaccines. Results from experiments in mice demonstrated a low antigenicity of the subunit vaccine in unprimed animals compared with that of whole-virus vaccine; however, the antigenicity of both vaccines was enhanced in mice primed by previous infection with HO and H1 viruses. In hamsters previously infected with an H3N2 virus, however, the response to only the whole-virus vaccine was enhanced by the priming infection. The responses of the mice were qualitatively more similar to those of humans than were the responses of hamsters.</div>
</front>
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Serveur d'exploration H2N2

Effect of Priming Infection on Serologic Response to Whole and Subunit Influenza Virus Vaccines in Animals

Effect of Priming Infection on Serologic Response to Whole and Subunit Influenza Virus Vaccines in Animals

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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